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Given their glucose-lowering effects, GLP-1s have become standard of care for type 2 diabetes, supplanting other medication classes such as sulfonylureas.2 In 2023, GLP-1s represented 63% of diabetes spend, up from 38% in 2020.2 While diabetes GLP-1s will continue to account for a greater portion of spend compared to obesity, costs related to GLP-1s prescribed for obesity are expected to grow at a faster rate over the next 3 years
Time-Restricted Eating (TRE) involves eating within a daily window, commonly: 16:8 (16-hour fast, 8-hour eating) 14:10 (easier to start) 12:12 (gentle beginning) Benefits of TRE: Reduces insulin exposure Promotes fat oxidation Improves appetite regulation Supports circadian rhythm Start with 12:12 , then extend as tolerated
involvement in the metabolism of estrogens, leukotrienes, and prostaglandins Improves DNA synthesis
For compounded formulations that need continuous refrigeration, a FRIO wallet alone is not sufficient
Cacciottola L, Donnez J, Dolmans MM (2021) Can endometriosis-related oxidative stress pave the way for new treatment targets
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