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Clinical case reports suggest discomfort is typically mild and transient, resolving as the body equilibrates
3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)
Potential Side Effects: Generally well-tolerated, but possible side effects may include mild irritation at the injection site or allergic reactions
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NICE recommends formal assessment of treatment response at 6 months, with continuation only if you've achieved an HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% (where weight loss is part of your treatment goals)
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