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Review Article: Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and Obesity Background More than 19 years after the first GLP1RA was introduced for type 2 diabetes and 10 years after its approval for obesity, innovations are expanding the use of GLP-1 medicines for metabolic disorders

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trimethylamine is efficiently absorbed and metabolized to trimethylamine- N -oxide, which is excreted in the urine (13)