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In mouse primary chondrocytes stimulated with IL-1, liraglutide treatment downregulated Tnf and nitric oxide synthase 2 (Nos2)
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Importantly, only Semaglutide and Tirzepatide are FDA-approved and available todayRetatrutide remains investigational, with realistic approval falling between the second half of 2027 and mid-2028
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By year four, fewer than half of those who achieved clinically significant loss had maintained it
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