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The combination of the SCD1 inhibitor arachidonyl trifluoromethyl ketone (ATF) and the deuterated sorafenib derivative donafenib has demonstrated promising antitumor effects in organoids and xenografted tumors derived from p53 wild-type HCC patients[228]
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Through the analysis of data from 19 randomized controlled trials, the researchers believe their work points to possible precision medicine applications of GLP-1s beyond just weight loss
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