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In line with these findings, a Danish pilot study demonstrated promoter hypomethylation of CLOCK and hypermethylation of CRY2 in peripheral blood DNA, potentially mediating the relationship between NSW and BC susceptibility 216
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The JACoP plugin for ImageJ (NIH) was used to calculate the colocalization rate for PC1/3 and glucagon for mouse islets and the colocalization rate for insulin and glucagon for human islets, as previously described (113)