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BMJ 2012;344.
Conclusion Intraventricular administration of streptozotocin (3 mg/kg, single bilateral injection) induces not only neuronal damage but also reactive astroglial changes, pronounced tanycyte degeneration, disruption of the ependymal lining in the third and lateral ventricles, astrocytic dysfunction, and altered distribution of aquaporin-4 and connexin-43 in hypothalamic structures
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Short courses of prednisolone typically have less impact on overall weight loss trajectory compared to longer-term therapy at higher doses
16, 17 This lack of clarity can lead to delayed help-seeking, misattribution of symptoms to ageing or sinister health issues, and reduced confidence in healthcare providers
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