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Dietary quality amplifies drug effects: GLP-1 receptor agonists reduce appetite and caloric intake, but the nutritional quality of consumed calories still matters for health outcomes
Semaglutide may cause worsening of diabetic retinopathy, particularly in patients with pre-existing retinopathy and when HbA1c is reduced rapidly
Recommended Target Glycemic Levels (2017 ADA Clinical Practice guidelines) Aim to achieve normal or near normal glycemia with an A1C goal of 5.5
Certain genetic variants affecting appetite regulation (like those mapped in PlexusDx's Precision Peptide Genetic Test) may influence how quickly weight returns after stopping medication
Many of those with side effects can be encouraged to restart therapy and gain the long-term benefits, including cardiovascular protection as seen in this trial.
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