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If you take semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound) and are dealing with frequent loose stools, you are not alone

The safety picture for investigational and research-grade compounds is far less certain

Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the GLP-1 receptor agonist

Sympathetic inhibition accompanied weight loss achieved by diet or surgery

The pivotal trials leading to FDA approval demonstrated reductions in visceral adipose tissue of approximately 15 to 20% over 26 weeks in HIV lipodystrophy patients, with continued reduction at 52 weeks