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We generated human brain organoids and cultivated them for 100-day-old to allow maturation of neuronal cells (Fig

IRE1 inhibition with KIRA6 or 48C reduces ER stress, neuronal death, and tau aggregation in PD, ALS, and AD models

This means fewer wasteful repeats, smoother workflows, and ultimately more efficient research

The use of the archived and anonymized medical records was approved with exempt status by the Institutional Review Board (IRB) of the University of North Carolina (UNC) at Chapel Hill, with the requirement of informed consent waived for retrospective use in computational research

Fasted administration is critical because the peptide works by stimulating lipolysis (fat breakdown) through beta-3 adrenergic receptor activation