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GLP-1 receptor activation slows gastric emptying (making food stay in the stomach longer, which extends satiety), reduces glucagon secretion (lowering blood sugar), and acts on hypothalamic neurons to reduce hunger drive
Certain medical conditions and medications increase B12 requirements: Long-term use of metformin (diabetes medication) or proton pump inhibitors (PPIs for acid reflux) can impair B12 absorption [13] [14] Gastrointestinal conditions such as Crohn's disease, coeliac disease, or previous gastric surgery Autoimmune conditions beyond pernicious anaemia may affect B12 metabolism When to contact your GP : If you are taking B12 supplements or receiving injections but continue to experience symptoms, request a review
Carbohydrates and fats blunt GH release
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