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Semaglutide is degraded by proteolytic enzymes and does not rely on hepatic cytochrome P450 metabolism, whilst topiramate undergoes limited hepatic metabolism and is primarily excreted unchanged in urine
10.1002/ejhf.657 42 KhanM
Industry reactions to the CagriSema results have been mixed at best
They found that the contaminant appeared able to inhibit the secretion of gastric acid (Brown, Magee)
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