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[6] A common cause of symmetric melanonychia that affects the great toe, the lateral and external portion of the fourth or fifth toenail, is recurrent trauma from overriding toes or poorly fitting shoes

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The broad search algorithm combined index terms and free-text words for all GLP-1-RAs, with no restriction to study language, design (including both individual studies and their meta-analyses), setting, comparator and outcome of interest to maximize the comprehensiveness of the evidence synthesis

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