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OT knockout mice used to confirm central versus peripheral effects Prairie voles Key model for social bonding research given natural pair-bonding behavior regulated by oxytocin/vasopressin systems Rhesus macaques Used in pharmacokinetic and neuroimaging studies with better translational validity than rodents Humans Unusually for a research peptide, a substantial body of randomized controlled trial data exists Cell culture OXTR-transfected cell lines used for binding and signaling studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite a large and growing body of research, the intranasal oxytocin field faces substantial replication challenges and mechanistic uncertainties that have tempered earlier enthusiasm
doi:10.1016/j.ejps.2008.07.005 35Crohns disease: management
416 While PDX models offer high fidelity and translational relevance, they are not without limitations
van Haeften, T
The kinetics of the contents of the blood compartment are complicated because GSH and its component amino acids in the blood interact with the kidney, the brain, and other tissues
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