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The EM structures (Figure 2b) of the receptor revealed that it is composed of: The extracellular domain (E) of the GLP-1 receptor binds the GLP-1 protein A seven transmembrane helical domain (TM1-7) with the -helices separated by three intracellular loops (IC1-3) and three extracellular loops (EC1-3) An intracellular (Cytoplasmic) C-terminus that interacts with G-Protein which is responsible for signaling The extracellular domain: The N-terminal ~120 amino acids of the extracellular domain of the GLP-1R protein has one long and one short helix, two beta strands forming a sheet and several loops joining these secondary structural elements

10.3389/fphar.2020.01132 32 BowenC

It has significantly helped with reducing dark spots, pigmentation, and acne scars

This dual-action approach not only addresses existing pigmentation concerns but also provides protection against environmental aggressors that can contribute to skin damage

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