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In that time, Ive watched the clinical culture around GLP-1s split in two directions

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Beyond the increased transcription of metabolic enzymes in semaglutide-treated animals, we also observed an increase in insulin signalling required for insulin-stimulated increase in glucose uptake and glycogen synthesis that is not shared by fibroblasts or endothelial cells ( Figure 3E-F )

Future work introducing modifiers with sufficient stacking ability while targeting other bases could extend this approach into a less biased platform

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