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People on tirzepatide lost about 50 pounds originally and gained an average ten pounds back after switching to orforglipron
While their mechanisms (BDNF upregulation, synaptogenesis) do not directly overlap with monoamine reuptake, the lack of interaction data makes concurrent use inadvisable without baseline and ongoing cardiovascular monitoring
They just involve physiology rather than pharmacology
PMID 2555512
Ensuring adequate protein and supplement intake is essential during tirzepatide therapy
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