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Pre-existing conditions such as type 2 diabetes, metabolic syndrome, and fatty liver disease also elevate gallstone probability during weight loss
A maintenance strategy matters: nutrition, resistance training, follow-up, medication adjustment, dose reduction, switching, or continued therapy depending on the patient
Notably, about one in four of these patients did not carry a type 2 diabetes diagnosis , suggesting that a substantial portion of GLP-1 use is being driven by weight loss and other emerging indications outside of diabetes care (Figure 2)
The profile of users is broader than commonly assumed
Adding retatrutide changes the metabolic environment significantly
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