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In a subanalysis of SURPASS-3, tirzepatide 10 and 15 mg resulted also in a relative reduction in liver fat content by 4047% compared to 11% with insulin glargine at 52 weeks [44]
However, Lilly stated that no major cardiac or liver safety issues were observed during the trial
Animal studies showed increased myocardiocyte glucose uptake and decreased reperfusion injury in dogs and rodents induced to have MI despite controlling for weight1
Rather than viewing aging as an inevitable part of life, many geroscientists now see it as a condition that could one day be slowed or modified, much like other diseases
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