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Harris if you experience: Persistent vomiting or signs of dehydration (dark urine, dizziness, dry mouth) Intense or ongoing abdominal pain Difficulty eating enough to maintain basic nutrition Any symptoms that feel severe or concerning to you You are never expected to push through discomfort Dr

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GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]

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Zhu Y, Ghosh P, Charnay P, Burns DK, Parada LF