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However, these are indicated only for acute exposure, and acetazolamide presents adverse effects such as paresthesia, dysgeusia, hyperglycemia, and rebound symptoms, limiting its long-term use ( Consequently, studies have evaluated antioxidant compounds such as vitamins C and E, -lipoic acid, and more recently standardized Ginkgo biloba extract, which has been attributed to potential antioxidant effects

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doi:10.1002/14651858.CD003945.pub4

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Natural Remedies: DIY masks for lightening the skin often contain lemon juice, aloe vera, and turmeric