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Patients with a BMI between 35 and 39.9 are increasingly being targeted for pharmacological treatment to prevent progression to more severe obesity and related complications
In February 2024, Regeneron announced plans to launch a phase 2 trial in mid-2024 that will test combining semaglutide for obesity with either trevogrumab or trevogrumab and garetosmab
These side effects are usually mild to moderate and often improve over time
PT-141 is FDA-approved (Vyleesi 2019) for hypoactive sexual desire disorder in women
However, NHS access criteria are more restrictive, typically requiring referral to specialist weight management services and higher BMI thresholds (generally 35 kg/m with comorbidities, with lower thresholds for some ethnic groups)
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