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Vitamin B12 is predominantly excreted via the bile and is largely reabsorbed via the enterohepatic circulation

Platelets release growth factors locally

Therefore only preservativefree sterile water should be used for neonates

Yet the consequences are unknown Bioavailability: there are four specific metabolic steps necessary to convert cyanocobalamin into one of the coenzyme forms, which is a clear metabolic disadvantage (3) Utilisation problems: certain hereditary diseases, as well as metabolic disorders, prevent the conversion of cyanocoalamin into the active B12 forms (4) Steals methyl groups: cyanocobalamin requires a methyl group to convert into methylcobalamin, which it takes from the important amino acid S-adenosylmethionine (SAM)

Dont inject into veins