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The team used methods that Daniell has refined to highly express the human version of IGF-1 in plant leaves and remove the antibiotic resistance gene that is used to select for plants growing the target protein, crucial steps to get a therapy ready for clinical use
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In a study by Wang et al., the F56-peptide-fused nanoparticles loaded with vincristine (F56-VCR-NP) were able to target both neovasculature and primary lesions of lung metastases, leading to neovasculature apoptosis and CRC tissue destruction [132]
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