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Over-the-Counter Remedies If lifestyle and dietary changes are not enough to relieve semaglutide constipation, over-the-counter remedies may be beneficial

Topical Application Topical application is the most common and accessible route

While the active ingredient is the same, compounded medications have not undergone the identical FDA approval process as brand-name versions

The delayed gastric emptying induced by semaglutide means the stomach retains food for longer periods, which may create the subjective experience of the stomach being "smaller" because patients feel full after consuming less food

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