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Alyftrek met that endpoint, and on the key secondary endpoint of sweat chloride reduction, it demonstrated superiority: in SKYLINE 102, sweat chloride decreased by 7.5 mmol/L with Alyftrek versus an increase of 0.9 mmol/L for Trikafta

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In an Australian epidemiological study [27], diabetes mellitus was associated with an increased prevalence of upper and lower GI symptoms, which were linked to poor glycemic control but not to duration of diabetes or type of treatment