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Dayan, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Due to DPP-4 and renal clearance, native GLP-1 in humans has a half-life of about 1-2 minutes (21, 22, 89)

144 GLP-1 RAs or a dual GLP-1/GIP RA as perpetrator drugs in combination with a victim drug, a number of clinical trials have been conducted to evaluate DDI potentials (Table 4 and Table 5)

The mechanisms are fundamentally different, and that difference has significant clinical implications