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Beyond direct radical neutralization, -TOH also plays a significant part in suppressing ROS generation by inhibiting NADPH-OX isoforms, particularly NADPH-OX2 and NADPH-OX4, which are up-regulated during seizure-induced glutamate excitotoxicity [49]
Then, step two would be the use of gentle nutrients in the form of supplements and nutraceuticals
Toxicology 207 , 349362 (2005)
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