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The sequences are shown below: G001: Sal-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH 2 G002: t3h-HAEGTFTSDVSSYZEGQAAKAFIEWLVKN-NH 2 Modification of the N-terminal histidine with acyl or benzoyl derivatives confers partial resistance to attack by DPP4, while introduction of a straight-chain alkyl group in position 14 of G002 helps to slow down elimination by the kidney by encouraging association with lipidic pockets in large proteins such as albumin or lipoproteins
This antioxidant activity displays the protective roles of UA action under physiological environment
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A 2025 post-hoc SURMOUNT-1 analysis ( Diabetes, Obesity and Metabolism ) confirmed Week 12 response is a strong predictor of long-term outcomes
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