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Multiple molecular mechanisms, activated by inflammatory mediators, contribute to the progression of HS.34,35 The prevalence of DT2 is higher in subjects with HS than in the general population.36 HS is also associated with other conditions traditionally linked with obesity, such as metabolic syndrome, polycystic ovarian syndrome, and inflammatory bowel disease,3739 and patients with HS are exposed to higher CVR than the general population.40 Obesity negatively impacts the response of patients to the main treatments for HS (Table S1 additional information).15 Advantages associated with weight loss in patients with obesity and psoriasis or hidradenitis suppurativa In addition to better response to treatments for inflammatory dermatoses, other arguments justify the desirability of patients with obesity and PsO or HS to lose weight
The severity of symptoms can vary depending on the amount ingested, and medical professionals should be consulted to determine the best course of action
A study demonstrated the neuroprotective effects of liraglutide, a commercially available GLP-1RA, on neuronal cells from H 2 O 2 -induced oxidative stress and glutamate-induced excitotoxicity, enhancing cell viability
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