The Wegovy pill was approved by the FDA in December 2025 as the first oral GLP-1 for weight loss
Context for other GLP-1 products The generic semaglutide approvals apply only to injectable semaglutide and do not affect tirzepatide products Mounjaro and Zepbound, which remain under patent in Canada
It is worth noting that the oral formulation of semaglutide (Rybelsus) does require specific administration instructions, including taking it on an empty stomach with no more than 4 ounces of water and waiting 30 minutes before eating, drinking, or taking other oral medications
Rzepczyk S, Dolinska-Kaczmarek K, Uruska A, Zaba C (2022) The Other Face of Insulin-Overdose and Its Effects, Toxics 10(3).10.3390/toxics10030123 Hatting M, Tavares C, Sharabi K, Rines AK, Puigserver P (2018) Insulin regulation of gluconeogenesis
CrossRef Resistin as Modulator of Functional Activity of Phagocytes in Colostrum and Blood of Overweight and Obese Mothers Carla Roberta Silva Souza Antnio, Elisia Possidnea Pereira, Danielle Cristina Honorio Frana, Patricia Gelli Feres de Marchi, Emanuelle Carolina Honorio Frana, Anibal Monteiro de Magalhes Neto, Elton Brito Ribeiro, Danny Laura Gomes Fagundes-Triches, Biomedicines.2025