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These results suggest that upon depletion of GSH, tissues undergo reprogramming to hyperactivate NRF2, possibly as a mechanism to upregulate adjacent antioxidant pathways and buffer oxidative stress induced upon GSH depletion
Melatonin acts as a potent antioxidant to combat the abundant free radicals produced in the mitochondria.[ref] Studies on Cancer, Aging, and Alzheimers: Cancer: Many recent studies have shown that melatonin acts directly to inhibit cancerous cells
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Aside from local defence, OPDA may be involved in long-distance signalling to facilitate the systemic propagation of immunity
