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This may suggest that acutely other GLP-1R-expressing sites are able to compensate for the loss of GLP-1R signaling, compensation that proves insufficient when LH GLP-1R is silenced in a chronic manner
Although lineage tracing or barcoding would be needed to confirm this, its plausible that ICB-induced transcriptional reprogramming leads to an increase in MES cells
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Sun Q, Lu NN, Feng L (2018) Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway