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To ascertain the obesity-specific role of TMPRSS2 in regulating postprandial glucose homeostasis, we employed an independent preclinical model of obesity (db/db mice) and performed a pharmacological intervention with a TMPRSS2 inhibitor
dose coupling identifies an exposure relationship, not the molecular pathway
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In Phase 3 trials, nausea affected up to 42.4% of people taking retatrutide, depending on the dose
Nutritional deficiencies such as iron deficiency anaemia, which can develop during significant dietary restriction, may also contribute
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