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Description

Noble et al

Allingham PG, Brownlee GR, Harper GS, ePho M, Nilsson SK, Brown TJ

FDA-Approved GLP-1 Medications Semaglutide and Tirzepatide provide clinically proven weight loss results

Existing GLP1R agonists come with boxed warnings of thyroid cancer and pancreatitis, based mainly on rodent studies, where the effects of GLP1R agonism have noted species differences (For example, weight loss in rodents is mainly due to increased energy expenditure, whereas in humans it occurs via less food intake [54] )

10.1016/j.jphs.2014.12.010 61 LiuT.YangL.GaoH.ZhuoY.TuZ.WangY.et al (2022)