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In fact, enteric neurons express transporters and receptors which are involved in sensing of main nutrients such as SGLT-1 (Na + d-glucose transporter) for glucose sensing, G-protein coupled receptor (GPR) 41 and 43 for short chain fatty acids (SCFAs) sensing, Pept2 (dipeptide transporter) and amino acid receptors activated by glutamate, glycine, or GABA for protein/peptide sensing [for review, see Ref