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doi: 10.3389/fmicb.2025.1577724 66
Phase I: modification, phase II: conjugation, and phase III: excretion
These findings reinforce the role of GLP-1RAs, and semaglutide in particular, as an important therapeutic option for patients with type 2 diabetes and established cardiovascular disease, supporting their inclusion in evidence-based guideline recommendations
Short-term side effects include flushing (related to vasodilation), nausea (mitigated by maintaining appropriate hydration status), brief headache, or dizziness/lightheadedness
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