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Description

Potent activation by BsAbs (e.g., BiTE-driven T-cell engagement) also increases the risk of systemic toxicities such as CRS (grade 3 with blinatumomab ~15%) and neurotoxicity, necessitating dose modulation, prophylaxis, and Fc-engineering-based risk mitigation

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Furthermore, some patients discontinue therapy because of: Expense Side effects Injection fatigue Medication shortages Real-world discontinuation rates remain substantial

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Both contain the same active ingredient at different dose ranges

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