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Dulaglutide's REWIND cardiovascular outcomes trial (N=9,901) did show a 12% reduction in major adverse cardiovascular events versus placebo over 5.4 years, which supports its use in patients with T2D and cardiovascular risk

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Endocrinology 137:23832388 Rouille Y, Martin S, Steiner DF (1995) Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide