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In contrast, there are studies revealing that the activation of HIF1 signaling is not principally regulated by mutant IDH1, but more likely via other recognized mechanisms like hypoxia, transcriptional regulation, and major genetic and epigenetic alterations induced by gain-of-function or loss-of-function mutations 30

Drug administration was carried out via intracerebroventricular injection following a standardized method described in previous literature

It signals the pituitary gland to release growth hormone

Appetite, mitochondrial signaling, GH response, and visceral-fat distribution are different questions

Safety profiles vary significantly between individuals based on genetic, inflammatory, and metabolic factors