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Health Canadas review of the safety data concluded that the safety profile of semaglutide tablets, including the frequency of GI AEs, was comparable to the other previously authorized GLP-1 RAs, including semaglutide injection
This makes them a safer option for long-term use
In addition, positive data in Nov 2024 from a phase 3 result on semaglutide will likely further broaden the available treatment landscape 4,5
These trials would provide more definitive evidence by directly comparing the medications to placebo and approved treatments in controlled settings
A common pattern is dropping retatrutide from 12 mg to 8 mg/week once cagrilintide is at 1.7-2.4 mg/week
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