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The breadth of DSIPs biological activity spanning sleep regulation, stress modulation, pain processing, antioxidant defence, and neuroprotection has led some researchers to characterise it as an adaptogenic peptide: one that supports homeostatic balance across multiple physiological systems rather than acting on a single discrete target

Other studies have shown that HT generates ROS and activates the phosphatidylinositol 3-kinase/Akt pathway, leading to FOXO3a(Forkhead box O3) phosphorylation and subsequent down-regulation, which induces apoptosis in DLD1 cells 31