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In blood pressure studies, the peptide did not affect basal blood pressure but counteracted both L-NAME-induced hypertension and L-arginine-induced hypotension
Clinical research suggested doses in the range of 1-10mcg per kilogram of body weight showed efficacy, though most protocols standardized around 4-6mcg/kg for practical application
Because controlled human research is limited, long-term side effects are not fully understood
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Perovic D, et al
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