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144 Among them, P-gp/ABCB1, 145 MDR-associated proteins (MRPs/ABCCs), 146 and BCRP/ABCG2 147 are most extensively studied
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In renal I/R injury, C3G increases GPX4 expression and GSH level, reverses excessive intracellular free iron accumulation, decreases lipid ROS, ACSL4, 4-HNE, and MDA levels, and significantly inhibits the ferroptosis of renal tubular cells
A variety of enzymes enriched in MAMs including Ero1 and ER resident protein 44 (ERp44) can lead to excessive production of mtROS
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