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Exendin-4, which shows 53% structural homology with GLP-1 (7-36), is as potent as endogenous GLP-1 in its insulinotropic effects via the mammalian GLP-1R
Compounded versions are typically 6085% less expensive and are legally available when the FDA has confirmed a shortage of the branded product, which has been ongoing for tirzepatide since 2024
While some suppliers meet acceptable standards, compounded products are not FDA-approved, and the final formulations may vary in purity, potency, and safety. FDA-approved drugs undergo a lengthy process, including research, rigorous testing, and clinical trials
A.SavasJ
Sermorelin's evidence base is almost entirely in GH-deficient populations (pediatric short stature, adult-onset GHD)
