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RSL3-treated K1 spheroids (48 h) were stained with propidium iodide (PI) to visualize dead cells within the spheroids

Supplementation may involve various forms of cobalamin: adenosylcobalamin, cyanocobalamin, methylcobalamin, or hydroxocobalamin

Clinicians can frame these outcomes as supportive and adjunctive rather than curative, emphasizing that GHK-Cu enhances the results of a comprehensive regimen rather than replacing cornerstone interventions such as sun protection, neuromodulators, or energy-based devices