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For one subject, the spectrum obtained at the second post-dose time point was of insufficient quality, and was omitted from analysis

Because the level of PAI-1 is correlated with atherosclerosis formation [41] and is markedly elevated in T2D patients with CVD compared with healthy or T2D patients without CVD [42], this result implies more fibrinolytic thereby less atherogenic processes

Study screening and selection A total of 1,384,265 articles were identified upon completion of the initial search using the selected search terms as shown in Fig