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METs cleave CXCL8 into active monomers to promote EMT and tumorendothelial adhesion and release matrix metalloproteinases (MMPs) to degrade ECM, facilitating metastasis

doi: 10.1016/j.cell.2010.06.028 35 MaLChenCZhaoCLiTMaLJiangJet al

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For example, EA was conjugated to 2-amino-2-deoxy-d-glucose (EAG) 90 , obtaining an adduct with significant anticancer activity such as EA but without the undesired diuretic activity 90