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Persistent inflammatory responses contribute to interstitial fibrosis, further accelerating kidney damage and systemic complications [145, 147]

Advanced manufacturing technologies and attractive packaging systems are also a major investment for modern pharmaceutical companies

Limitations and Mixed Results Many studies have small sample sizes or short durations, making it hard to draw firm conclusions

A small but significant portion undergoes cytochrome P450 (CYP2E1) oxidation, producing the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI)