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Figure 3 In conclusion, SLC7A11 has a pro-survival effect, and SLC7A11-mediated cystine uptake can help cells re-establish redox homeostasis in response to oxidative stress, whereas inhibition of SLC7A11 can lead to depletion of cellular GSH and thus make the cells more sensitive to chemotherapy or radiotherapy
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Samms RJ, Christe ME, Collins KA et al (2021) GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice
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